p38α has an important role in antigen cross-presentation by dendritic cells
نویسندگان
چکیده
منابع مشابه
β2-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells.
Despite widespread usage of β-adrenergic receptor (AR) agonists and antagonists in current clinical practice, our understanding of their interactions with the immune system is surprisingly sparse. Among the AR expressed by dendritic cells (DC), β2-AR can modify in vitro cytokine release upon stimulation. Because DC play a pivotal role in CD8(+) T cell immune responses, we examined the effects o...
متن کاملHistamine improves antigen uptake and cross-presentation by dendritic cells.
Previous studies have shown that histamine is able to modulate the function of dendritic cells (DCs). Histamine seems to be required for the normal differentiation of DCs. Moreover, it is capable of stimulating the chemotaxis of immature DCs and of promoting the differentiation of T CD4+ cells into a Th2 profile. In this study, we analyzed whether histamine was able to modulate endocytosis and ...
متن کاملThe dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.
Mouse spleens contain three populations of conventional (CD11c(high)) dendritic cells (DCs) that play distinct functions. The CD8(+) DC are unique in that they can present exogenous antigens on their MHC class I molecules, a process known as cross-presentation. It is unclear whether this special ability is because only the CD8(+) DC can capture the antigens used in cross-presentation assays, or...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2016
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2016.49